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TOPIC: Ingredients for life


L

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Amino Acid Chirality
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NASA scientists analysing the dust of meteorites have discovered new clues to a long-standing mystery about how life works on its most basic, molecular level.

"We found more support for the idea that biological molecules, like amino acids, created in space and brought to Earth by meteorite impacts help explain why life is left-handed. By that I mean why all known life uses only left-handed versions of amino acids to build proteins" - Dr. Daniel Glavin of NASA's Goddard Space Flight Centre in Greenbelt, Md.

Glavin is lead author of a paper on this research appearing in the Proceedings of the National Academy of Sciences March 16.

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Soggy rocks hurtling through the solar system gave life on Earth an addiction to left-handed proteins, according to a new study. The research suggests that water on asteroids amplified left-handed amino acid molecules, making them dominate over their right-handed mirror images.
Curiously, almost every living organism on Earth uses left-handed amino acids instead of their right-handed counterparts. In the 1990s, scientists found that meteorites contain up to 15% more of the left version too. That suggests space rocks bombarding the early Earth biased its chemistry so that life used left-handed amino acids instead of right.

"Meteorites would have seeded the Earth with some of the prebiotic compounds like amino acids that are needed to get life started, and also biased the origin of life to the left-handed amino acid form" - Daniel Glavin at NASA's Goddard Space Flight Centre in Greenbelt, Maryland.

Some have suggested that polarised starlight preferentially destroyed right-handed amino acids on asteroids. But this alone couldn't explain why the meteorite bias is so strong.
Now Glavin and colleague Jason Dworkin have shown that water amplified the asymmetry.

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RE: Ingredients for life
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Processes that laid the foundation for life on Earth -- star and planet formation and the production of complex organic molecules in interstellar space -- are yielding their secrets to astronomers armed with powerful new research tools, and even better tools soon will be available.
Astronomers described three important developments at a symposium on the "Cosmic Cradle of Life" at the annual meeting of the American Association for the Advancement of Science in Chicago, IL.
In one development, a team of astrochemists released a major new resource for seeking complex interstellar molecules that are the precursors to life. The chemical data released by Anthony Remijan of the National Radio Astronomy Observatory (NRAO) and his university colleagues is part of the Prebiotic Interstellar Molecule Survey, or PRIMOS, a project studying a star-forming region near the center of our Milky Way Galaxy.
PRIMOS is an effort of the National Science Foundation's Center for Chemistry of the Universe, started at the University of Virginia (UVa) in October 2008, and led by UVa Professor Brooks H. Pate. The data, produced by the NSF's Robert C. Byrd Green Bank Telescope (GBT) in West Virginia, came from more than 45 individual observations totalling more than nine GigaBytes of data and over 1.4 million individual frequency channels.

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Scientists are puzzled as frozen life forms get exposed in the asteroids. The frozen life forms means the ingredients of life forms waiting for high velocity impact to form amino acids, the starting of the evolution cycle.
The association of the most abundant population of meteorites, the ordinary chondrites, and the S-type asteroids through the comparison of their reflected spectra in the visible and near infrared spectrum, is still widely debated.

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One of life's greatest mysteries is how it began. Scientists have pinned it down to roughly this:
Some chemical reactions occurred about 4 billion years ago - perhaps in a primordial tidal soup or maybe with help of volcanoes or possibly at the bottom of the sea or between the mica sheets - to create biology.

Now scientists have created something in the lab that is tantalisingly close to what might have happened. It's not life, they stress, but it certainly gives the science community a whole new data set to chew on.
The researchers, at the Scripps Research Institute, created molecules that self-replicate and even evolve and compete to win or lose. If that sounds exactly like life, read on to learn the controversial and thin distinction.


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RNA
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One of the most enduring questions is how life could have begun on Earth. Molecules that can make copies of themselves are thought to be crucial to understanding this process as they provide the basis for heritability, a critical characteristic of living systems. New findings could inform biochemical questions about how life began.
Now, a pair of Scripps Research Institute scientists has taken a significant step toward answering that question. The scientists have synthesized for the first time RNA enzymes that can replicate themselves without the help of any proteins or other cellular components, and the process proceeds indefinitely.
The work was recently published in the journal Science.
In the modern world, DNA carries the genetic sequence for advanced organisms, while RNA is dependent on DNA for performing its roles such as building proteins. But one prominent theory about the origins of life, called the RNA World model, postulates that because RNA can function as both a gene and an enzyme, RNA might have come before DNA and protein and acted as the ancestral molecule of life. However, the process of copying a genetic molecule, which is considered a basic qualification for life, appears to be exceedingly complex, involving many proteins and other cellular components.
For years, researchers have wondered whether there might be some simpler way to copy RNA, brought about by the RNA itself. Some tentative steps along this road had previously been taken by the Joyce lab and others, but no one could demonstrate that RNA replication could be self-propagating, that is, result in new copies of RNA that also could copy themselves.

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Glycolaldehyde
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The search for life beyond Earth doesn't always require rovers on Mars, radio scans of nearby stars or telescopes powerful enough to image Earth-like planets. For some astronomers, learning about whether life exists elsewhere in the universe is a matter of molecules.
Maria Beltran, with the University of Barcelona's Department of Astronomy, and several European colleagues found a fairly simple molecule known as glycolaldehyde, an eight-atomed entity -- two carbon, two oxygen, four hydrogen -- more commonly known as sugar.
What's interesting about glycolaldehyde is how easily it combines with a three-carbon sugar to produce ribose, the building blocks of DNA and RNA, which carry genetic information for living things.

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RE: Ingredients for life
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Japanese researchers have given us a new glimpse into the beginnings of life on Earth by recreating a meteoric collision into the sea to generate the building blocks of life, a British scientific journal reported Monday.
Hiromoto Nakazawa, fellow emeritus at the National Institute of Materials Science in Tsukuba, Ibaraki Prefecture, along with a research team at Tohoku University succeeded in recreating the moment a meteor crashes into the ocean, generating amino acid and other bioorganic molecules that comprise the basis of life.


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While space rocks hurtling in from space threaten to deal modern life a mortal blow, meteorite impacts during Earth's early history may have played a pivotal role in kick-starting life on the planet.
Exactly how and when organic molecules appeared in abundance on the young Earth, leading to the origin of life about 4 billion years ago, has been unclear. But new research suggests that meteor impacts could have created amino acids, the building blocks of life.

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Many theories about the origins of life on Earth posit that prebiotic compounds may have arrived from outer space on asteroids or comets. But a new study suggests that extreme chemical reactions fired up by meteorite impacts may have jump-started life in the early oceans, rather than delivering its building blocks preformed. Meteorites striking the primordial oceans, the paper's authors say, could have supplied significant amounts of carbon, critical to life, and created a sort of chemical pressure cooker by the force of their impacts to synthesize the foundations of biological molecules.
The researchers report in Nature Geoscience today that they replicated the impact of a chondrite, a common type of meteorite, striking the ocean at about two kilometres per second. The team did this by subjecting chemical constituents of chondrites (iron, nickel and carbon), as well as water and nitrogen, believed to be plentiful in the early atmosphere, to shock compression. The resulting pressures and temperatures, which likely exceeded 2,760 degrees Celsius, yielded a variety of organic compounds,

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